Comparative effect of 25(OH)D3 and 1,25(OH)2D3 on Th17 cell differentiation.


Vitamin D is a secosteroid hormone that plays an important regulatory role in calcium homeostasis and bone metabolism. Immune cells can both produce and respond to 1,25(OH)2D3. CD4+ T cells from vitamin D receptor (VDR) KO mice produce higher levels of IFN-γ and IL-17 than their wild type counterparts, and play a crucial role in the pathogenesis of… (More)
DOI: 10.1016/j.clim.2016.02.011