Comparative distribution and metabolism of triamcinolone acetonide and cortisol in the rat embryomaternal unit.

Abstract

Triamcinolone acetonide (TAC) is teratogenic in rats while cortisol has been reported as not teratogenic. The objective of this investigation was to determine whether this difference in teratogenicity could be due to a difference in the metabolism and distribution of the parent compound in the embryomaternal unit. 3H-TAC and 14C-cortisol were administered… (More)

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