Comparative distribution and embryotoxicity of acetylsalicylic acid in pregnant rats and rhesus monkeys.

  title={Comparative distribution and embryotoxicity of acetylsalicylic acid in pregnant rats and rhesus monkeys.},
  author={J. Gerald Wilson and E. J. Ritter and William J. Scott and Rochelle Fradkin},
  journal={Toxicology and applied pharmacology},
  volume={41 1},
Comparative distribution and embryotoxicity of methotrexate in pregnant rats and rhesus monkeys.
A slow rate of fall in embryo concentrations in both species was estimated to be inversely proportioned to the rate of growth of embryos, which was in accord with the fact that the absolute amount per embryo was little changed in 24 hours.
Embryonal disposition of salicylate: in vivo-in vitro comparisons.
The distribution of salicylate to embryonal compartments for in situ and in vitro rat embryos under equivalent exposure conditions, and salicylate disposition in the in vivo mid-gestation embryo and
Diflunisal-induced maternal anemia as a cause of teratogenicity in rabbits.
It is demonstrated that a species that exhibits unusually severe drug-specific maternotoxicity is probably an unsuitable model for the prediction of the teratogenic potential of that drug in humans.
Teratologic potential of 2-methoxyethanol and transplacental distribution of its metabolite, 2-methoxyacetic acid, in non-human primates.
It is indicated that 2-ME is a potent toxin to the developing primate embryo and thereby furthers the concern about exposure of pregnant women to this agent, although maternal toxicity was evident in nearly all treated pregnancies and was especially severe in the high-dosage animals.
Aspirin: teratogenic evaluation in the dog.
Examination of fetuses from 12 untreated litters and 4 vehicle-control litters revealed a very low spontaneous malformation rate confined almost entirely to minor tail abnormalities, which support use of the dog as an acceptable alternative species in teratogenic screening.
Species differences in pharmacokinetics and drug teratogenesis.
  • H. Nau
  • Biology, Medicine
    Environmental health perspectives
  • 1986
It is concluded that the prediction of the human response based on animal studies can be improved by consideration of the appropriate pharmacokinetic determinants, and it must be investigated if peak concentrations or the area under the concentration-time curve (AUC) correlate with the teratogenic response.


Comparative distribution and embryotoxicity of hydroxyurea in pregnant rats and rhesus monkeys.
Although the teratogenic effects were not identical in the two species, these data are interpreted to mean that rat embryos are teratogenically much more sensitive to hydroxyurea than monkey embryos, which has important implications in the selection of appropriate species for tests to estimate human teratogens risks.
Studies on metabolism and identification of the causative agent in aspirin teratogenesis in rats.
Pregnant Wistar rats treated orally with 250, 500, 750, or 1000 mg/kg aspirin showed a teratogenic dose-response relation at each treatment time, but a decreased overall embryonic susceptibility as treatment was applied later in gestation, implicating salicylic acid as the causative agent in aspirin teratogenesis.
Breeding and pregnancy in rhesus monkeys used for teratological testing.
Clomiphene citrate did not improve conception rate in relatively infertile animals above that observed in untreated animals with similar reproductive histories, and early abortions after teratological tests were diagnosed by uterine palpation.
Experimental production of congenital malformations in rats by salicylate poisoning.
This work has attempted the experimental production of congenital malformations by large doses of salicylates because the pathologic physiology ofsalicylate poisoning has been thoroughly investigated and because it seemed possible that some of the known metabolic effects of salingylates could be specifically responsible for disturbed embryogenesis.
Associations between Drugs Administered during Pregnancy and Congenital Abnormalities of the Fetus
During pregnancy, it would appear wise to avoid the administration of any drug which carries a suspicion of teratogenicity unless that drug is specifically indicated, and self-medication with common household remedies such as aspirin and antacids should be avoided.
Salicylate‐Induced Fetal Death and Malformations in Two Mouse Strains
Sodium salicylate was given i.m. in a single dose on one gestation day (9th, 11th, 13th, 15th or 17th) to pregnant primiparous mice of A/Jax and CBA strains and of their reciprocal crossings. The
Teratogenic drugs--R.C.G.P. survey.
The young doctor is faced with the painful necessity of having to earn a living, particularly as he is likely to be married and often has a family to support, and decides on radiology as a career.
Congenital malformations and environmental influences in pregnancy.
  • I. Richards
  • Medicine
    British journal of preventive & social medicine
  • 1969
A retrospective analysis of 833 consecutive cases of malformations and an equal number of matched controls found significant differences between cases and controls when first trimester salicylate intake was compared suggesting that either Salicylates or the conditions for which they are given have a teratogenic effect.
Associations between oral clefts and drugs taken during pregnancy.
  • I. Saxén
  • Medicine
    International journal of epidemiology
  • 1975
Associations between drug consumption during pregnancy and the birth of children with oral clefts were studied in material from the Finnish Register of Congenital Malformations, consisting of 599
A rapid method for the determination of salicylate binding by the use of ultrafilters
An ultrafiltration method that combines speed, simplicity, accuracy and precision was employed to measure plasma binding of salicylate, and yields results comparable to those obtained by equilibrium dialysis.