Comparative disposition and metabolism of 1,2,3-trichloropropane in rats and mice.

@article{Mahmood1991ComparativeDA,
  title={Comparative disposition and metabolism of 1,2,3-trichloropropane in rats and mice.},
  author={Naushin Mahmood and D W Overstreet and Leo T. Burka},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1991},
  volume={19 2},
  pages={411-8}
}
1,2,3-Trichloropropane (TCP) has been used as a solvent and degreasing agent and as an intermediate in pesticide manufacture. TCP is currently the subject of a National Toxicology Program chronic toxicity study. The present study is part of a larger effort to characterize the toxicity of TCP. Following acute oral exposure of male and female F344 rats (30 mg/kg) and male B6C3F1 mice (30 and 60 mg/kg), TCP was rapidly absorbed, metabolized, and excreted. The major route of excretion of TCP was in… CONTINUE READING