Comparative disposition, receptor affinity, and teratogenic activity of sulfon arotinoids.

@article{Willhite1995ComparativeDR,
  title={Comparative disposition, receptor affinity, and teratogenic activity of sulfon arotinoids.},
  author={Calvin C. Willhite and Arnaud Dubois and Janice Schindler-Horvat and Christian C. Apfel and Ch. Eckhoff},
  journal={Teratology},
  year={1995},
  volume={52 3},
  pages={169-75}
}
To investigate the relationship between sulfon arotinoid biotransformation and teratogenic activity, the potency of the ethyl (Ro 15-1570) and methyl (Ro 14-9706) arotinoid sulfones and their in vivo disposition in pregnant hamsters were studied. Administration of Ro 15-1570 was teratogenic, but Ro 14-9706 showed no such activity. Total absorbed doses of… CONTINUE READING