Comparative characterization of experimental and calculated lipophilicity and anti-tumour activity of isochromanone derivatives.

@article{Huszr2010ComparativeCO,
  title={Comparative characterization of experimental and calculated lipophilicity and anti-tumour activity of isochromanone derivatives.},
  author={M{\'e}nika Husz{\'a}r and Attila Varga and Anton Horv{\'a}th and Tam{\'a}s L{\'o}r{\'a}nd and Attila Ag{\'o}cs and Mikl{\'o}s Idei and J{\^o}zsef Mandl and Tibor V{\'a}ntus and Gy{\"o}rgy K{\'e}ri},
  journal={Current medicinal chemistry},
  year={2010},
  volume={17 4},
  pages={
          321-33
        }
}
Compound lipophilicity connected to ADME(T)(a) has great importance in drug development and it has to be evaluated by the generally used drug developmental process. In addition to the importance of lipophilicity in ADMET, recently it has been reported that lipophilicity of small molecules correlates with their antiproliferative activity because of certain specific hydrophobic and lipophilic interactions. Due to the complexity of ADME(T) parameters an efficient and fast method is needed to… CONTINUE READING