Comparative characterisation of poly(ADP-ribose) polymerase-1 from two mammalian species with different life span

@article{Beneke2000ComparativeCO,
  title={Comparative characterisation of poly(ADP-ribose) polymerase-1 from two mammalian species with different life span},
  author={Sascha Beneke and Rafael Alvarez-Gonz{\'a}lez and Alexander B{\"u}rkle},
  journal={Experimental Gerontology},
  year={2000},
  volume={35},
  pages={989-1002}
}
DNA damage induced in higher eukaryotes by alkylating agents, oxidants or ionising radiation triggers the synthesis of protein-conjugated poly(ADP-ribose) catalysed by poly(ADP-ribose) polymerase-1 (PARP-1). Previously, cellular poly(ADP-ribosyl)ation capacity has been shown to correlate positively with the life span of mammalian species [Proc. Natl. Acad. Sci. USA 89 (1992) 11,759-11,763]. Here, we have tested whether this correlation results from differences in kinetic parameters of the… Expand
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DNA strand breaks induced by alkylating agents, oxidants or ionizing radiation trigger the covalent modification of nuclear proteins with poly(ADP-ribose), which is catalysed for the most part byExpand
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