Comparative carcinogenesis by nitrosomorpholines, nitrosooxazolidines and nitrosotetrahydrooxazine in rats.

@article{Lijinsky1982ComparativeCB,
  title={Comparative carcinogenesis by nitrosomorpholines, nitrosooxazolidines and nitrosotetrahydrooxazine in rats.},
  author={W. Lijinsky and M. Reuber},
  journal={Carcinogenesis},
  year={1982},
  volume={3 8},
  pages={
          911-5
        }
}
  • W. Lijinsky, M. Reuber
  • Published 1982
  • Biology, Medicine
  • Carcinogenesis
  • A comparison was made of the carcinogenic effectiveness of some cyclic nitrosamines containing oxygen in the ring. The compounds were administered to F344 rats at approximately equimolar concentrations in drinking water. Nitrosomorpholine, nitroso-1,3-oxazolidine and nitrosotetrahydro-1,3-oxazine were of similar potency and gave rise to hepatocellular carcinomas and angiosarcomas of the liver in almost 100% of treated rats. Methyl substitution at the beta position of nitrosomorpholine increased… CONTINUE READING
    20 Citations
    Carcinogenesis in rats by cyclic N-nitrosamines containing sulphur.
    • W. Lijinsky, R. Kovatch, +4 authors W. Fiddler
    • Chemistry, Medicine
    • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
    • 1988
    • 12
    Structure-activity relations in carcinogenesis by N-nitroso compounds
    • W. Lijinsky
    • Biology, Medicine
    • Cancer and Metastasis Reviews
    • 2004
    • 84
    N-Nitroso Compounds†
    Dose-response study with N-nitrosodiethanolamine in F344 rats.
    • W. Lijinsky, M. Reuber
    • Medicine
    • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
    • 1984
    • 19
    Genotoxicology of N-Nitroso Compounds
    • 29
    • PDF
    Combined chronic toxicity and carcinogenicity studies of morpholine oleic acid salt in B6C3F1 mice.
    • 6