Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine.

@article{Balestrini2016ComparativeBO,
  title={Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine.},
  author={Jenna Leigh Balestrini and Ashley L Gard and Kristin A. Gerhold and Elise C Wilcox and Angela Liu and Jonas Schwan and Andrew V Le and Pavlina Baevova and Sashka Dimitrievska and Liping Zhao and Sumati Sundaram and Huanxing Sun and Laure Ritti{\'e} and Rachel N Dyal and Tom J. Broekelmann and Robert P. Mecham and Martin A Schwartz and Laura E. Niklason and Eric S White},
  journal={Biomaterials},
  year={2016},
  volume={102},
  pages={220-30}
}
Lung engineering is a promising technology, relying on re-seeding of either human or xenographic decellularized matrices with patient-derived pulmonary cells. Little is known about the species-specificity of decellularization in various models of lung regeneration, or if species dependent cell-matrix interactions exist within these systems. Therefore decellularized scaffolds were produced from rat, pig, primate and human lungs, and assessed by measuring residual DNA, mechanical properties, and… CONTINUE READING
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