Comparative bioavailability of two oral metamizole formulations. Influence of the acetylation phenotype.

@article{Bacracheva1995ComparativeBO,
  title={Comparative bioavailability of two oral metamizole formulations. Influence of the acetylation phenotype.},
  author={N. Bacracheva and A Drenska and J Gorantcheva and Nadejda Tyutyulkova and Vitan Dakov Vlahov},
  journal={Arzneimittel-Forschung},
  year={1995},
  volume={45 3},
  pages={
          282-5
        }
}
The bioavailability of the four metabolites of metamizole (CAS 68-89-3), 4-methyl-amino-antipyrine (4-MAA), 4-formyl-amino-antipyrine (4-FAA), 4-amino-antipyrine (4-AA) and 4-acetyl-amino-antipyrine (4-AcAA) was compared after oral administration of a test (Analgin) and a reference formulation, both containing 1 g of metamizole. The study was conducted in 12 healthy volunteers according to an open, randomized, cross-over design. The geometric mean of the area under the serum concentration-time… CONTINUE READING

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