Comparative bioavailability of two oral formulations of clozapine in steady state administered in schizophrenic volunteers under individualized dose regime.

Abstract

In the present study, a novel, fast, sensitive and robust method to quantify clozapine in human plasma using quetiapine as the internal standard (IS) is described. The analyte and the IS were extracted from plasma using a single protein precipitation extraction technique with methanol and analyzed by high performance liquid chromatography coupled to the… (More)

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@article{Borges2012ComparativeBO, title={Comparative bioavailability of two oral formulations of clozapine in steady state administered in schizophrenic volunteers under individualized dose regime.}, author={Ney Carter do Carmo Borges and Rafael Barrientos Astigarraga and Carlos Eduardo Sverdloff and Paulo Alexandre Rebelo Galvinas and Bruno Carter Borges and Ronilson Agnaldo Moreno}, journal={Current clinical pharmacology}, year={2012}, volume={7 4}, pages={241-53} }