Comparative bioavailability of two flurbiprofen products: stereospecific versus conventional approach.

@article{Jamali1991ComparativeBO,
  title={Comparative bioavailability of two flurbiprofen products: stereospecific versus conventional approach.},
  author={Fakhreddin Jamali and Donley S. Collins and Brian William. Berry and S. Molder and Ramsey Cheung and K Mccoll and Helen Cheung},
  journal={Biopharmaceutics & drug disposition},
  year={1991},
  volume={12 6},
  pages={
          435-45
        }
}
In this randomized, crossover study comparing the bioavailability of a film-coated (Ansaid) with a sugar-coated (Froben) 100 mg tablets of racemic flurbiprofen in 23 healthy young men, no significant differences were found for Cmax, tmax or AUC, using a nonstereoisomeric assay for flurbiprofen. Minor differences in the appearance of flurbiprofen in serum during the first 30-min post-dosing period were noted, with Ansaid appearing earlier than Froben. These differences likely reflect dissolution… CONTINUE READING
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