Comparative bioavailability of a cisapride suppository and tablet formulation in healthy volunteers

  title={Comparative bioavailability of a cisapride suppository and tablet formulation in healthy volunteers},
  author={Thomas Hedner and Jan Hedner and A. Gelin-Friberg and M. L. Huang and S. Poel and Robert Woestenborghs and Achiel van Peer and Jos J.P. Heykants},
  journal={European Journal of Clinical Pharmacology},
SummaryThe comparative bioavailability of cisapride as a 30 mg suppository and three 5 mg oral tablets was investigated in 12 non-smoking, healthy male volunteers. The two formulations were administered on two separate occasions following an overnight fast, according to a randomized cross-over design. The plasma concentration of cisapride was measured over 48 h after drug administration. The 30 mg suppository exhibited a mean time to the peak plasma concentration of 3.8 h, while the tablets… 
8 Citations

Mechanism of action of the cisapride-induced vasodilatation in renal vasculature of rat.

The findings indicated that cisapride caused vasodilatation through therelease of nitric oxide as a result of the release of a substance acting on muscarinic receptors, in the renal vascular bed of the rat.

Maturation of cytochrome P450 3A mediated drug metabolism: Towards individualized dosing in children

Most drugs have not been adequately studied in children, leaving this population at an increased risk of underdosing or toxicity, and an increase in the number of studies investigating long-term effects, i.e. neurodevelopmental outcome in children.

Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment.

  • J. DorneK. WaltonA. Renwick
  • Medicine, Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2003

Effect of cisapride on distal colonic motility in the early postoperative period following left colonic anastomosis

Although cisapride may have a differential effect on the colon proximal and distal to an anastomosis and significantly increases some indices of motility in the early postoperative period, these are unlikely to be of any clinical relevance.

Determination of cisapride in human plasma by high-performance liquid chromatography with fluorescence detection

SummaryA new sensitive HPLC-FLD method has been developed and validated for the determination of cisapride in human plasma for a bioequivalence study. A gradient method was used to remove

The effect of a single rectal dose of cisapride on delayed gastric emptying

Background: Cisapride has an established prokinetic effect in patients with delayed gastric emptying. However, rectal administration of the drug might be preferred in patients with either dysphagia

Effect of peppermint oil and caraway oil on gastrointestinal motility in healthy volunteers: a pharmacodynamic study using simultaneous determination of gastric and gall‐bladder emptying and orocaecal transit time

Background : Although peppermint oil and caraway oil are frequently used in herbal drugs for abdominal discomfort and pain, the pharmacological insights into their effects on the gastrointestinal

Immune responses of a liposome/ISCOM vaccine adjuvant against streptococcal fibronectin binding protein 1 (Sfb1) in mice.

The data suggest that the SAMA4 adjuvant used in this study fails to elicit protective immunity in BALB/c mice when used to adjuvanted the known protective antigen Sfb1.



Excretion and biotransformation of cisapride in dogs and humans after oral administration.

The excretion and biotransformation of cisapride, a novel gastrokinetic drug, were studied after a single po dose of [14C]cisapride in dogs and humans to find out whether there was more amine conjugation in dogs or not.

Cisapride. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use as a prokinetic agent in gastrointestinal motility disorders.

Should future results support preliminary evidence of comparable efficacy to metoclopramide, domperidone and ranitidine (in oesophagitis), cisapride with its favourable tolerability profile should claim a prominent position in the therapy of patients with a variety of gastrointestinal motility disorders.

Statistical analysis of bioavailability studies: Parametric and nonparametric confidence intervals

Two nonparametric methods and their adaptations to bioavailability ratios are reviewed, one based on Wilcoxon's signed rank test (Tukey), and the other on Pitman's permutation test.

[Cisapride: pharmacology, current therapeutic results and future prospects].

Le mecanisme d'action du cisapride est lie a une stimulation de la liberation d'acetylcholine au niveau des terminaisons nerveuses des plexus myanteriques. Resultats des principaux travaux de

Pharmacokinetics of cisapride in healthy volunteers

  • 1986

Pharmacokinetics of cisapride in healthy volunteers. Digestion: 34:130

  • Dr. T. Hedner Department of Clinical Pharmacology Sahlgren's University Hospital S-413
  • 1986