Comparative behavioral effects of several anticholinergic agents in rats

@article{Pradhan2004ComparativeBE,
  title={Comparative behavioral effects of several anticholinergic agents in rats},
  author={Sachin N. Pradhan and Thomas Roth},
  journal={Psychopharmacologia},
  year={2004},
  volume={12},
  pages={358-366}
}
SummaryThe behavioral effects of JB 329 (Ditran) were compared with those of several anticholinergic agents in rats.The tertiary nitrogen-containing compounds (i.e. JB 329, JB 336, atropine, scopolamine) caused an increase in their spontaneous motor activity, decrease in food and water intake and an over-all decrease in the response in the various phases of the multiple schedules of reinforcement (i.e. shock avoidance, fixed-ratio water reinforcement, and time-out). The potency of JB 329 was… Expand
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References

SHOWING 1-10 OF 22 REFERENCES
Some effects of muscarinic cholinergic blocking drugs on behavior and the electrocorticogram
TLDR
It is suggested that the disruption of the acquisition, but not retention, of conditioned avoidance is due to a deficit of recent memory, and a possible site of action of cholinergic blocking drugs is proposed. Expand
An examination of central actions characteristic of scopolamine: Comparison of central and peripheral activity in scopolamine, atropine and some synthetic basic esters
SummaryA survey of the literature shows that in many central actions, scopolamine has about 10 times the activity of atropine, whereas the ratio for most peripheral actions is nearer 2. For effectsExpand
CHOLINERGIC BLOCKADE AS AN APPROACH TO THE DEVELOPMENT OF NEW PSYCHOTROPIC AGENTS
The emergence of the psychotropic drugs as effective therapeutic agents in the treatment of mental disorders and the subsequent attempts to elucidate their mechanism of action, brought to theExpand
Anticholinergic Drugs and the Central Control of Thirst
TLDR
Atropine and scopolamine were compared with their centrally inactive quaternary analogs for effects on water and food intake in rats, and all drugs inhibited eating, but only the centrally active compounds inhibited drinking. Expand
Pharmacology of the central cholinergic synapses.
  • Z. Votava
  • Chemistry, Medicine
  • Annual review of pharmacology
  • 1967
Some behavioral effects of Ditran (JB 329) in rats.
A ~ ooD : Studies of a new drug ( Ditran ) in depression states
  • Pharmacol . Rev .
  • 1966
...
1
2
3
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