Comparative autoradiographic distribution of neuropeptide Y Y1 receptors visualized with the Y1 receptor agonist [125I][Leu31,Pro34]PYY and the non-peptide antagonist [3H]BIBP3226.

Abstract

BIBP3226, a non-peptide neuropeptide Y Y1 receptor antagonist, was used in its tritiated form to investigate the autoradiographic distribution of its binding sites in the rat brain. [125I][Leu31,Pro34]pPYY a recently developed Y1 agonist radioligand was used for comparison. High levels of specific binding for both radioligands were seen in various areas of… (More)

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