Comparative assessment of saliva and plasma for drug bioavailability and bioequivalence studies in humans.

@article{Idkaidek2017ComparativeAO,
  title={Comparative assessment of saliva and plasma for drug bioavailability and bioequivalence studies in humans.},
  author={Nasir M. Idkaidek},
  journal={Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society},
  year={2017},
  volume={25 5},
  pages={671-675}
}
Aims: To study the pharmacokinetics of selected drugs in plasma and saliva matrixes in healthy human volunteers, and to suggest using non-invasive saliva sampling instead of plasma as a surrogate in bioavailability and bioequivalence (BA/BE) studies. Methods: Four different pilot BA/BE studies were done in 12-18 healthy humans. Saliva and plasma samples… CONTINUE READING