Comparative assessment of efficacy and withdrawal symptoms after 6 and 12 weeks' treatment with diazepam or buspirone.

@article{Murphy1989ComparativeAO,
  title={Comparative assessment of efficacy and withdrawal symptoms after 6 and 12 weeks' treatment with diazepam or buspirone.},
  author={S. Murphy and R. Owen and P. Tyrer},
  journal={The British journal of psychiatry : the journal of mental science},
  year={1989},
  volume={154},
  pages={
          529-34
        }
}
  • S. Murphy, R. Owen, P. Tyrer
  • Published 1989
  • Psychology, Medicine
  • The British journal of psychiatry : the journal of mental science
Fifty-one out-patients presenting with generalised anxiety disorder were included in a double-blind trial, and treated with either buspirone (a new non-benzodiazepine antianxiety drug) or diazepam over 6 or 12 weeks, after which they were abruptly withdrawn and continued on placebo to 14 weeks. Ratings of anxiety and other symptoms were administered fortnightly and additional withdrawal symptoms noted. Forty patients completed the study; 8 of the 11 drop-outs were taking buspirone. Both drugs… Expand
A double-blind placebo-controlled study of buspirone in diazepam withdrawal in chronic benzodiazepine users.
TLDR
Overall, buspirone did not appear to be helpful in alleviating benzodiazepine withdrawal symptoms and higher subjectively rated anxiety at the start of withdrawal was significantly related to higher dropout rate. Expand
Assessment of the efficacy of buspirone in patients affected by generalized anxiety disorder, shifting to buspirone from prior treatment with lorazepam: a placebo-controlled, double-blind study.
TLDR
The results showed that buspirone was more effective than placebo and comparable to lorazepam, and benzodiazepine-withdrawal syndrome was evaluated through a 27-symptom checklist at weeks 0, 5, 6, 7, 11, and 13. Expand
Efficacy of Buspirone in the Treatment of Opioid Withdrawal
TLDR
Buspirone, a nonopiate drug with no abuse potential, a safe side effect profile and no withdrawal symptoms, was as effective as a methadone taper in alleviating the withdrawal symptoms of heroin addicts. Expand
Controlled comparison of the effects and abrupt discontinuation of buspirone and lorazepam
  • M. Bourin, M. Malinge
  • Psychology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1995
TLDR
It is confirmed that buspirone was as effective as lorazepam at D56 in monitored outpatients with generalized anxiety disorder, and similar efficacy during the active phase with a higher significant difference for buspir one on the CHESS 84 in relation with neurovegetatives symptoms. Expand
Overlap of buspirone with lorazepam, diazepam and bromazepam in patients with generalized anxiety disorder: Findings from a controlled, multicentre, double‐blind study
In a controlled, randomized, multicenter, double‐blind study involving 335 patients with generalized anxiety disorder, buspirone (Busp) was compared to lorazepam, diazepam or bromazepam in order toExpand
WITHDRAWAL FROM BENZODIAZEPINES IN A HOSPITAL SETTING: AN OPEN TRIAL WITH BUSPIRONE
TLDR
The results point out the possibility of abruptly stopping benzodiazepine compounds and substituting them with buspirone; however, it is suggested that psychological support, as available in a hospital setting, may be required. Expand
Buspirone vs Alprazolam: A Double-Blind Comparative Study of Their Efficacy, Adverse Effects and Withdrawal Symptoms
TLDR
Results of this study indicate a superiority of buspirone over alprazolam with regard to adverse effects and withdrawal symptoms. Expand
Absence of withdrawal effects of ritanserin following chronic dosing in healthy volunteers
TLDR
Ritanserin discontinuation following chronic dosing in healthy volunteers does not appear to be associated with withdrawal symptoms and levels of anxiety, concentration, quality of sleep and morning vigilance were measured throughout. Expand
Key considerations for long-term studies with anxiolytics.
  • M. Placchi
  • Psychology, Medicine
  • European psychiatry : the journal of the Association of European Psychiatrists
  • 1996
TLDR
There is the need to establish diagnostic criteria for persistent anxiety for patients who truly benefit from long-term therapy and risk factors predisposing to drug dependence should be assessed prior to continuous use. Expand
The efficacy of complaints management training in facilitating benzodiazepine withdrawal.
TLDR
CMT proved more successful than AMT in terms of abstinence rate, reported number of severe withdrawal symptoms, depression and anxiety, and at follow-up after 6 months, there was no difference between groups. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 37 REFERENCES
Controlled study of withdrawal symptoms and rebound anxiety after six week course of diazepam for generalised anxiety.
TLDR
The results suggest that diazepam can produce rebound anxiety and withdrawal symptoms when used in moderate doses and for what has previously been regarded as a safe length of time. Expand
GRADUAL WITHDRAWAL OF DIAZEPAM AFTER LONG-TERM THERAPY
TLDR
Examination of pharmacological and clinical predictors of withdrawal phenomena and later relapse showed that personality factors were the most important, patients with passive-dependent traits having a significantly greater prevalence of withdrawal reactions. Expand
BENZODIAZEPINE WITHDRAWAL SYMPTOMS AND PROPRANOLOL
40 patients seen in general practice and psychiatric outpatient clinics who had taken lorazepam or diazepam alone in regular dosage for a mean period of 3.6 years had their benzodiazepine replaced byExpand
Comparison of Buspirone and Diazepam in Generalized Anxiety Disorder
TLDR
Total scores from the Hamilton anxiety scale and physician's global ratings show that diazepam was significantly superior to buspirone during the initial 2 weeks of treatment, which is further corroborated by the results of patients' self‐rated scales. Expand
Withdrawal reaction after long-term therapeutic use of benzodiazepines.
TLDR
It is concluded that a clinically important, mild, but distinct withdrawal syndrome occurs after discontinuation of long-term therapeutic use of benzodiazepines. Expand
A double-blind comparison of buspirone and diazepam in outpatients with generalized anxiety disorder.
TLDR
The safety and antianxiety and antidepressive effects of buspirone were compared in a double-blind trial with those of diazepam and were nearly equivalent in relieving symptoms of both anxiety and depression in 100 patients. Expand
Withdrawal from long-term benzodiazepine treatment.
TLDR
Because of the risk of dependence on benzodiazepines these agents should probably not be given as regular daily treatment for chronic anxiety. Expand
Buspirone and diazepam in anxiety: a controlled study.
TLDR
Those who improved most were married, well-educated females who had both a positive family adjustment and a low level of depression, while buspirone appears more effective in reducing symptoms associated with cognitive and interpersonal problems. Expand
Withdrawal reaction from long-term, low-dosage administration of diazepam. A double-blind, placebo-controlled case study.
TLDR
With long-term administration of diszepam, even in therapeutically accepted doses, withdrawal reactions can be encountered on abrupt termination, as verified in a study conducted under placebo-controlled, double blind conditions. Expand
Anxiety in primary care: is short-term drug treatment appropriate?
TLDR
The results suggest that the common practice of giving short-term therapy with tranquilising drugs for anxiety in primary care is pharmacologically suspect. Expand
...
1
2
3
4
...