Comparative assays for the HER-2/neu oncogene status in breast cancer.

  title={Comparative assays for the HER-2/neu oncogene status in breast cancer.},
  author={Jos{\'e} Mar{\'i}a Vera-Rom{\'a}n and Luis Alberto Rubio-Mart{\'i}nez},
  journal={Archives of pathology & laboratory medicine},
  volume={128 6},
CONTEXT Tumor marker assays, especially those used to indicate the right therapy, should be standardized. OBJECTIVE To analyze the current methods for the HER-2/neu (h2n) oncogene status by immunohistochemical (IHC) analysis, fluorescence in situ hybridization (FISH), and chromogenic in situ hybridization (CISH) and compare those results with the chromosome 17 copy number and the status of the topoisomerase II alpha (TPIIalpha) gene. DESIGN We tested 50 infiltrating ductal breast carcinomas… CONTINUE READING
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