Comparative aspects of zebrafish (Danio rerio) as a model for aging research.


The zebrafish has emerged over the past decade as a major model system for the study of development due to its invertebrate-like advantages coupled with its vertebrate biology. These features also make it a potentially valuable organism for gerontological research. The main advantages of zebrafish include its economical husbandry, small yet accessible size, high reproductive capacity, genetic tractability, and a large and growing biological database. Although zebrafish life span is longer than rodents, it shares the feasibility of large-scale mutational analysis with the extremely short-lived invertebrate models. This review compares zebrafish with the more widely used model organisms used for aging research, including yeast, worms, flies, mice, and humans.

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@article{Gerhard2003ComparativeAO, title={Comparative aspects of zebrafish (Danio rerio) as a model for aging research.}, author={Glenn S. Gerhard}, journal={Experimental gerontology}, year={2003}, volume={38 11-12}, pages={1333-41} }