Comparative aspects of osteosarcoma. Dog versus man.

@article{Withrow1991ComparativeAO,
  title={Comparative aspects of osteosarcoma. Dog versus man.},
  author={Stephen J. Withrow and Barbara E. Powers and Rod C Straw and Ross M. Wilkins},
  journal={Clinical orthopaedics and related research},
  year={1991},
  volume={270},
  pages={
          159-68
        }
}
Canine osteosarcoma bears striking resemblance to osteosarcoma in humans. Similarities include the following: male sex predilection, large patient size, 75% or more affecting the appendicular site, metaphyseal location, generally unknown etiology, less than 10% of patients have documented metastasis at presentation, over 90% of tumors show high-grade histology, 75% of tumors show aneuploidy, the metastatic rate is 80% or more with amputation alone, the lung is the most common site of metastasis… Expand
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Appendix B: Canine Osteosarcoma
Similaritiesbetween canine and human osteosarcoma includemetaphyseal occurrence, typical metastasis to lungsand other bones, and response to doxorubicin andplatinum-based protocols. CanineExpand
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