Comparative aspects of osteosarcoma. Dog versus man.

  title={Comparative aspects of osteosarcoma. Dog versus man.},
  author={Stephen J. Withrow and Barbara E. Powers and Rod C Straw and Ross M. Wilkins},
  journal={Clinical orthopaedics and related research},
Canine osteosarcoma bears striking resemblance to osteosarcoma in humans. Similarities include the following: male sex predilection, large patient size, 75% or more affecting the appendicular site, metaphyseal location, generally unknown etiology, less than 10% of patients have documented metastasis at presentation, over 90% of tumors show high-grade histology, 75% of tumors show aneuploidy, the metastatic rate is 80% or more with amputation alone, the lung is the most common site of metastasis… Expand
Estudo clínico de osteossarcoma canino Clinical study of canine osteosarcoma
The clinical and epidemiological findings of this study corroborate the literature, making them increasingly used in the auxiliary tests cited and of great value in the diagnosis and prognosis of this tumor and may demonstrate metastases when elevated. Expand
Risk Factors for Development of Canine and Human Osteosarcoma: A Comparative Review
Risk factors for the development of osteosarcoma in dogs and humans are described, including height and body size, genetics, and conditions that increase turnover of bone-forming cells, underscoring the concept that stochastic mutational events associated with cellular replication are likely to be the major molecular drivers of this disease. Expand
Vet. Sci
  • 2015
Comparative Aspects of Osteosarcoma Pathogenesis in Humans and Dogs
Known causative factors that predispose to the development OS in human beings and dogs are summarized in detail and it is likely that foundational discoveries in one species will be translationally relevant to the other and emphasizes the unique opportunities that might be gained through comparative scientific approaches. Expand
Oral and maxillofacial osteosarcoma in dogs: a review.
Osteosarcoma in dogs is a heterogeneous disease entity with regard to its histologic, clinical and biologic behaviour, and these also appear to have less aggressive behaviour than appendicular osteosarComa in humans. Expand
Animal models of osteosarcoma
  • T. Fan
  • Medicine
  • Expert review of anticancer therapy
  • 2010
It is anticipated that specific animal models of OS, which most accurately recapitulate the natural disease process in people, will be most useful for advancing the understanding of OS biology, and will facilitate the discovery of disease pathogenesis and the identification of novel therapeutic strategies for managing this lethal metastatic bone sarcoma. Expand
Appendix B: Canine Osteosarcoma
Similaritiesbetween canine and human osteosarcoma includemetaphyseal occurrence, typical metastasis to lungsand other bones, and response to doxorubicin andplatinum-based protocols. CanineExpand
Murine and Canine Models of Appendicular Osteosarcoma
  • T. Fan
  • Medicine
  • Current protocols in pharmacology
  • 2007
This unit provides a protocol for using an orthotopic, syngeneic murine model of appendicular OSA as an investigative tool for the study of OSA biology and the comparative relevance of spontaneously occurring appendicular osteosarcoma in canines for theStudy of pediatric bone sarcomas is discussed. Expand
Simultaneous occurrence of fibroblastic osteosarcoma and hypertrophic osteopathy (Marie’s disease) in a German shepherd dog
This is the first report of simultaneous occurrence of fibroblastic osteosarcoma and Marie’s disease in Iranian dogs. Expand
Height as a risk factor in osteosarcoma.
  • A. Longhi, A. Pasini, +4 authors G. Bacci
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2004
The higher incidence during the pubertal spurt, in the anatomic sites of greater growth and in taller individuals, suggests that the GH-IGF axis may play a role in the pathogenesis of osteosarcoma, in agreement with a number of previous experimental studies. Expand