Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species.

@article{Zou2007ComparativeAT,
  title={Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species.},
  author={Sige Zou and Jason Sinclair and Mark A. Wilson and James R. Carey and Pablo Liedo and Azucena Oropeza and Avash Kalra and Rafael de Cabo and Donald K. Ingram and Dan L. Longo and Catherine A. Wolkow},
  journal={Mechanisms of ageing and development},
  year={2007},
  volume={128 2},
  pages={222-6}
}
Many compounds hold promise for pharmacologic manipulation of aging. However, such claims are difficult to investigate due to time and budget constraints. Here, we took a comparative approach, using short-lived invertebrate species, to directly test the effects of two tocopherols (Vitamin E) on longevity. gamma-Tocopherol represents the most abundant tocopherol in the Western diet, while alpha-tocopherol is selectively enriched in human plasma. Both isoforms demonstrate antioxidant activity and… CONTINUE READING