Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats.

@article{Pruneau1987ComparativeAE,
  title={Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats.},
  author={Didier Pruneau and France Roy},
  journal={Arzneimittel-Forschung},
  year={1987},
  volume={37 4},
  pages={416-8}
}
Effects of two dihydropyridine derivatives, nifedipine and nicardipine, on systolic blood pressure and heart rate in adult (4- to 5-month-old) spontaneously hypertensive rats (SHR) were studied in comparison with those in aged (11- to 12-month-old) SHR. Both calcium channel blockers induced similar dose-dependent hypotensive effects in 4- to 5-month- and 11- to 12-month-old SHR. The maximal hypotensive action of both calcium channel blockers was delayed in aged SHR compared to adult SHR… CONTINUE READING

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Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
It is concluded that nifedipine and nicardipine are potent antihypertensive agents in aged SHR which differently affect heart rate .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
It is concluded that nifedipine and nicardipine are potent antihypertensive agents in aged SHR which differently affect heart rate .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
DihydropyridinesChemical structure ofNicardipine
Effects of two dihydropyridine derivatives , nifedipine and nicardipine , on systolic blood pressure and heart rate in adult ( 4- to 5-month - old ) spontaneously hypertensive rats ( SHR ) were studied in comparison with those in aged ( 11- to 12-month - old ) SHR .
DihydropyridinesChemical structure ofNifedipine
Effects of two dihydropyridine derivatives , nifedipine and nicardipine , on systolic blood pressure and heart rate in adult ( 4- to 5-month - old ) spontaneously hypertensive rats ( SHR ) were studied in comparison with those in aged ( 11- to 12-month - old ) SHR .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
Effects of two dihydropyridine derivatives , nifedipine and nicardipine , on systolic blood pressure and heart rate in adult ( 4- to 5-month - old ) spontaneously hypertensive rats ( SHR ) were studied in comparison with those in aged ( 11- to 12-month - old ) SHR .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
Effects of two dihydropyridine derivatives , nifedipine and nicardipine , on systolic blood pressure and heart rate in adult ( 4- to 5-month - old ) spontaneously hypertensive rats ( SHR ) were studied in comparison with those in aged ( 11- to 12-month - old ) SHR .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
It is concluded that nifedipine and nicardipine are potent antihypertensive agents in aged SHR which differently affect heart rate .
Effects of two dihydropyridine derivatives , nifedipine and nicardipine , on systolic blood pressure and heart rate in adult ( 4- to 5-month - old ) spontaneously hypertensive rats ( SHR ) were studied in comparison with those in aged ( 11- to 12-month - old ) SHR .
Effects of two dihydropyridine derivatives , nifedipine and nicardipine , on systolic blood pressure and heart rate in adult ( 4- to 5-month - old ) spontaneously hypertensive rats ( SHR ) were studied in comparison with those in aged ( 11- to 12-month - old ) SHR .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
It is concluded that nifedipine and nicardipine are potent antihypertensive agents in aged SHR which differently affect heart rate .
In contrast to nicardipine there was no increase in heart rate after administration of nifedipine in aged SHR at same hypotensive effects .
It is concluded that nifedipine and nicardipine are potent antihypertensive agents in aged SHR which differently affect heart rate .
In contrast to nicardipine there was no increase in heart rate after administration of nifedipine in aged SHR at same hypotensive effects .
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats .
Effects of two dihydropyridine derivatives , nifedipine and nicardipine , on systolic blood pressure and heart rate in adult ( 4- to 5-month - old ) spontaneously hypertensive rats ( SHR ) were studied in comparison with those in aged ( 11- to 12-month - old ) SHR .
Effects of two dihydropyridine derivatives , nifedipine and nicardipine , on systolic blood pressure and heart rate in adult ( 4- to 5-month - old ) spontaneously hypertensive rats ( SHR ) were studied in comparison with those in aged ( 11- to 12-month - old ) SHR .
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