Comparative antifungal activities and plasma pharmacokinetics of micafungin (FK463) against disseminated candidiasis and invasive pulmonary aspergillosis in persistently neutropenic rabbits.

@article{Petraitis2002ComparativeAA,
  title={Comparative antifungal activities and plasma pharmacokinetics of micafungin (FK463) against disseminated candidiasis and invasive pulmonary aspergillosis in persistently neutropenic rabbits.},
  author={Vidmantas Petraitis and Ruta Petraitiene and Andreas H Groll and Kristin C Roussillon and Melissa Hemmings and Caron A. Lyman and Tin Aung Sein and John Bach{\'e}r and Ihor Bekersky and Thomas J Walsh},
  journal={Antimicrobial agents and chemotherapy},
  year={2002},
  volume={46 6},
  pages={1857-69}
}
Micafungin (FK463) is an echinocandin that demonstrates potent in vitro antifungal activities against Candida and Aspergillus species. However, little is known about its comparative antifungal activities in persistently neutropenic hosts. We therefore investigated the plasma micafungin pharmacokinetics and antifungal activities of micafungin against experimental disseminated candidiasis and invasive pulmonary aspergillosis in persistently neutropenic rabbits. The groups with disseminated… CONTINUE READING