Comparative antidepressant effects of intravenous and intrathecal thyrotropin-releasing hormone: confounding effects of tolerance and implications for therapeutics.

@article{Callahan1997ComparativeAE,
  title={Comparative antidepressant effects of intravenous and intrathecal thyrotropin-releasing hormone: confounding effects of tolerance and implications for therapeutics.},
  author={A M Callahan and Mark A. Frye and Lauren B. Marangell and Mark S. George and Terence A. Ketter and T A L'Herrou and Robert M Post},
  journal={Biological psychiatry},
  year={1997},
  volume={41 3},
  pages={264-72}
}
A significant amount of preclinical and human data indicate that thyrotropin-releasing hormone (TRH) has antidepressant effects. Although early studies showing these effects using intravenous TRH were not consistently replicated, it has been suggested that this could be explained by its poor blood-brain barrier penetration. For this reason we compared the antidepressant effect of intrathecal and intravenous TRH administered in a double-blind design to 2 treatment-refractory patients with… CONTINUE READING

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