Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis.

@article{Credito2008ComparativeAA,
  title={Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis.},
  author={Kim L Credito and Lois M. Ednie and Peter C. Appelbaum},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 1},
  pages={
          365-73
        }
}
  • Kim L Credito, Lois M. Ednie, Peter C. Appelbaum
  • Published in
    Antimicrobial agents and…
    2008
  • Biology, Medicine
  • Against 447 anaerobe strains, the investigational carbapenem doripenem had an MIC 50 of 0.125 microg/ml and an MIC 90 of 1 microg/ml. Results were similar to those for imipenem, meropenem, and ertapenem. Time-kill studies showed that doripenem had very good bactericidal activity compared to other carbapenems, with 99.9% killing of 11 strains at 2x MIC after 48 h. 

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