Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury.

@article{Proctor2004ComparativeAA,
  title={Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury.},
  author={Lavinia M. Proctor and Thiruma Valavan Arumugam and Ian A. Shiels and Robert C Reid and David P. Fairlie and Stephen M. Taylor},
  journal={British journal of pharmacology},
  year={2004},
  volume={142 4},
  pages={
          756-64
        }
}
1. Complement activation is implicated in the pathogenesis of intestinal ischaemia-reperfusion injury (I/R), although the relative importance of individual complement components is unclear. A C3a receptor antagonist N(2)-[(2,2-diphenylethoxy)acetyl]-l-arginine (C3aRA) has been compared with a C5a receptor antagonist (C5aRA), AcF-[OPdChaWR], in a rat model of intestinal I/R. 2. C3aRA (IC(50)=0.15 microm) and C5aRA (IC(50)=0.32 microm) bound selectively to human polymorphonuclear leukocyte (PMN… CONTINUE READING
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