Comparative and meta-analytic insights into life extension via dietary restriction.

  title={Comparative and meta-analytic insights into life extension via dietary restriction.},
  author={Shinichi Nakagawa and Malgorzata Lagisz and Katie L Hector and Hamish G. Spencer},
  journal={Aging cell},
  volume={11 3},
Dietary restriction (DR) extends the lifespan of a wide range of species, although the universality of this effect has never been quantitatively examined. Here, we report the first comprehensive comparative meta-analysis of DR across studies and species. Overall, DR significantly increased lifespan, but this effect is modulated by several factors. In general, DR has less effect in extending lifespan in males and also in non-model organisms. Surprisingly, the proportion of protein intake was… CONTINUE READING
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