Comparative and meta‐analytic insights into life extension via dietary restriction

@article{Nakagawa2012ComparativeAM,
  title={Comparative and meta‐analytic insights into life extension via dietary restriction},
  author={Shinichi Nakagawa and Malgorzata Lagisz and Katie L. Hector and Hamish G. Spencer},
  journal={Aging Cell},
  year={2012},
  volume={11}
}
Dietary restriction (DR) extends the lifespan of a wide range of species, although the universality of this effect has never been quantitatively examined. Here, we report the first comprehensive comparative meta‐analysis of DR across studies and species. Overall, DR significantly increased lifespan, but this effect is modulated by several factors. In general, DR has less effect in extending lifespan in males and also in non‐model organisms. Surprisingly, the proportion of protein intake was… Expand
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References

SHOWING 1-10 OF 53 REFERENCES
Aging and survival: the genetics of life span extension by dietary restriction.
TLDR
How recent work in nonmammalian model organisms has revealed new insight into the genetics of DR and how the discovery of DR-specific transcription factors will advance the understanding of this phenomenon are discussed. Expand
Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening
TLDR
The results demonstrate that the lifespan response to a single level of DR exhibits wide variation amenable to genetic analysis and show that DR can shorten lifespan in inbred mice, raising the possibility that life extension by DR may not be universal. Expand
Calories Do Not Explain Extension of Life Span by Dietary Restriction in Drosophila
TLDR
It is demonstrated that extension of life span by DR in Drosophila is not attributable to the reduction in calorie intake, and reduction of either dietary yeast or sugar can reduce mortality and extend life span, but by an amount that is unrelated to the calorie content of the food. Expand
Why dietary restriction substantially increases longevity in animal models but won’t in humans
TLDR
A hypothesis-neutral model describing the relationship between diet and longevity is developed and indicates that the benefits of caloric restriction in humans would be quantitatively small. Expand
Dietary restriction and aging: comparative tests of evolutionary hypotheses.
  • K. Kirk
  • Biology, Medicine
  • The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2001
TLDR
There was support for the idea that the response to chronic DR is associated with changes in reproductive allocation during short-term periods of starvation: species that reduced reproduction when starved increased their life span under DR, whereas species that continued to reproduce when starved decreased their life spans under DR. Expand
Lifespan and reproduction in Drosophila: New insights from nutritional geometry
TLDR
The use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster indicates a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein. Expand
Dietary restriction and aging: a unifying perspective.
TLDR
Examples are provided showing that it is more informative to analyze DR in terms of dietary balance and that dietary optimization for life span is critical for studies examining the biology of aging and other traits. Expand
Does caloric restriction extend life in wild mice?
TLDR
No difference in mean longevity between ad libitum (AL) and CR dietary groups is found, although a maximum likelihood fitted Gompertz mortality model indicated a significantly shallower slope and higher intercept for the CR group, and a strong anticancer effect of CR is noted. Expand
Caloric restriction and aging revisited: the need for a geometric analysis of the nutritional bases of aging.
  • S. Simpson, D. Raubenheimer
  • Biology, Medicine
  • The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2007
TLDR
The conclusion is that Drosophila provides the most suitable system for an initial study of the relationship between nutrition and aging, and the development of state-space geometric models, the Geometric Framework, is introduced. Expand
Nutrients, not caloric restriction, extend lifespan in Queensland fruit flies (Bactrocera tryoni)
TLDR
It is demonstrated that CF can overcome dietary dilutions, reveal difficulties with methods presenting fixed amounts of liquid diet and illustrate the need to measure intake to account for CF in DR studies, and highlight nutrients rather than CR as a dominant influence on LS. Expand
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1
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4
5
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