Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells.

@article{Dervovi2012ComparativeAF,
  title={Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells.},
  author={D{\vz}ana D. Dervovi{\'c} and Maria Ciofani and Korosh Kianizad and Juan Carlos Z{\'u}{\~n}iga-Pfl{\"u}cker},
  journal={Journal of immunology},
  year={2012},
  volume={189 7},
  pages={3411-20}
}
The generation of the cytotoxic CD8 T cell response is dependent on the functional outcomes imposed by the intrathymic constraints of differentiation and self-tolerance. Although thymic function can be partly replicated in vitro using OP9-DL1 cell cultures to yield CD8 αβ TCR-bearing cells from hematopoietic progenitor cells, a comprehensive and functional assessment of entirely in vitro generated CD8 T cells derived from bone marrow hematopoietic stem cells has not been established and remains… CONTINUE READING