Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases.

@article{Tan2009ComparativeAR,
  title={Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases.},
  author={Chris S. H. Tan and Bernd Bodenmiller and Adrian Pasculescu and Marko Jovanovi{\'c} and Michael O. Hengartner and Claus Bo J{\o}rgensen and Gary D. Bader and Ruedi Aebersold and Tony Pawson and Rune Linding},
  journal={Science signaling},
  year={2009},
  volume={2 81},
  pages={
          ra39
        }
}
  • Chris S. H. Tan, Bernd Bodenmiller, +7 authors Rune Linding
  • Published in Science signaling 2009
  • Biology, Chemistry, Medicine
  • Protein kinases enable cellular information processing. Although numerous human phosphorylation sites and their dynamics have been characterized, the evolutionary history and physiological importance of many signaling events remain unknown. Using target phosphoproteomes determined with a similar experimental and computational pipeline, we investigated the conservation of human phosphorylation events in distantly related model organisms (fly, worm, and yeast). With a sequence-alignment approach… CONTINUE READING

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