Comparative analysis of two meningococcal immunotyping monoclonal antibodies by resonant mirror biosensor and antibody gene sequencing.

@article{Charalambous1999ComparativeAO,
  title={Comparative analysis of two meningococcal immunotyping monoclonal antibodies by resonant mirror biosensor and antibody gene sequencing.},
  author={Bambos M Charalambous and Jessica Evans and Ian M. Feavers and Martin C J Maiden},
  journal={Clinical and diagnostic laboratory immunology},
  year={1999},
  volume={6 6},
  pages={838-43}
}
Lipooligosaccharide (LOS) is a major surface component of the cell walls of Neisseria meningitidis, which is important for its roles in pathogenesis and antigenic variation, as a target for immunological typing, and as a possible vaccine component. Although the structures of many antigenic variants have been determined, routine immunological typing of these molecules remains problematic. Resonant mirror analysis was combined with gene sequencing to characterize two monoclonal antibodies (MAbs… CONTINUE READING
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