Comparative analysis of theophylline and cholera toxin in rat colon reveals an induction of sealing tight junction proteins

  title={Comparative analysis of theophylline and cholera toxin in rat colon reveals an induction of sealing tight junction proteins},
  author={A. Markov and E. L. Falchuk and N. M. Kruglova and O. V. Rybalchenko and M. Fromm and S. Amasheh},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  • A. Markov, E. L. Falchuk, +3 authors S. Amasheh
  • Published 2014
  • Biology, Medicine
  • Pflügers Archiv - European Journal of Physiology
  • Claudin tight junction proteins have been identified to primarily determine intestinal epithelial barrier properties. While functional contribution of single claudins has been characterized in detail, information on the interplay with secretory mechanisms in native intestinal epithelium is scarce. Therefore, effects of cholera toxin and theophylline on rat colon were analyzed, including detection of sealing claudins. Tissue specimens were stripped off submucosal tissue layers and mounted in… CONTINUE READING
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