Comparative analysis of the structural and expressional parameters of microRNA target genes.

@article{Mok2012ComparativeAO,
  title={Comparative analysis of the structural and expressional parameters of microRNA target genes.},
  author={Young-Joon Mok and Seung Gu Park and Sun Shim Choi},
  journal={Gene},
  year={2012},
  volume={497 1},
  pages={103-9}
}
MicroRNAs (miRNAs) generally pair with the 3'UTRs of their target mRNAs to repress gene expression. It has reported that miRNA targets (TGs) are longer and evolve more slowly than non-targets (NTGs). We confirmed the observation and also found novel structural and expressional characteristics of TGs. The length difference between TGs and NTGs was greatest for the 3'UTRs, although a difference was also observed for CDSs and introns. Widely expressed genes were shorter for both TGs and NTGs… CONTINUE READING