Comparative analysis of the expression and oncogenic activities of Xenopus c-, N-, and L-myc homologs.

@article{SchreiberAgus1993ComparativeAO,
  title={Comparative analysis of the expression and oncogenic activities of Xenopus c-, N-, and L-myc homologs.},
  author={Nicole Schreiber-Agus and Richard Torres and James F Horner and Agnes E Lau and Milan Jamrich and Ronald A. Depinho},
  journal={Molecular and cellular biology},
  year={1993},
  volume={13 4},
  pages={2456-68}
}
A polymerase chain reaction-based cloning strategy allowed for the isolation of two distinct Xenopus L-myc genes, as well as previously isolated xc- and xN-myc genes, thus demonstrating that these three well-defined members of the mammalian myc gene family are present in lower vertebrates as well. Comparison of the Xenopus and mammalian Myc families revealed a high degree of structural relatedness at the gene and protein levels; this homology was consistent with the ability of the xc-myc1 and… CONTINUE READING

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