Comparative analysis of the effects of adapromine, midantane, and bromantane on bioelectrical activity of rat brain

  title={Comparative analysis of the effects of adapromine, midantane, and bromantane on bioelectrical activity of rat brain},
  author={S. V. Krapivin and Svetlana Alexandrovna Sergeeva and I. S. Morozov},
  journal={Bulletin of Experimental Biology and Medicine},
The adamantane derivatives adapromine, midantane, and bromantane modify bioelectrical activity of brain cortex and subcortical structures. Neurophysiological effects of these preparations indicate that they possess psychostimulating activity. The effect of bromantane on electrical potentials from left and right sensorimotor cortex, dorsal hippocampus, and lateral hypothalamus was stronger than that of adapromine and midantane. This effect was observed as greater quantitative changes in the… 
3 Citations
Conformationally restricted GABA analogs: from rigid carbocycles to cage hydrocarbons.
In an effort to increase the lipophilicity and to reduce conformational flexibility of GABA itself, a polycyclic or cage hydrocarbon framework can be introduced into the 3D structure of GABA in order to better control the binding.
Investigation of Reaction of Some Ester Ethoxycarbonyl Hydrazones with 1-Adamantyl Amine
I n this study, the reactions of the 1-adamantyl amine with 4 different ester ethoxycarbonyl hydrazone derivatives were studied. At first, iminoester hydrochloride derivatives were synthesized
A Convenient Road to 1-Chloropentacycloundecanes – A Joint Experimental and Computational Investigation
An efficient synthetic strategy to obtain 1-chloro-C s -trishomocubane and 1-chloro-D 3 -trishomocubane is described. 1-Chloro-C s -trishomocubane is synthesized by a regioselective Diels-Alder


Radioelectroencephalographic comparison of memantine with receptor-specific drugs acting on dopaminergic transmission in freely moving rats.
The results are in accordance with the drug's proposed action of enhancing the dopaminergic transmission, which probably implies an indirect mechanism of action as biochemically no direct interaction with any of the dopamine receptors has been described for memantine so far.
Germane, Experimental and Clinical Pharmacotherapy
  • [in Russian],
  • 1986
Screening of New Neurotropic Preparations [in Russian
  • 1983
Tsaune, Experimental and Clinical Pharmacotherapy
  • [in Russian],
  • 1986