Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5.

@article{Soars2006ComparativeAO,
  title={Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5.},
  author={Matthew G. Soars and Kenneth H Grime and Rob Riley},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2006},
  volume={36 4},
  pages={287-99}
}
To evaluate the role that cytochrome (CYP) 3A5 plays in hepatic drug metabolism, the substrate selectivity and inhibitory potential of over 60 compounds towards CYP3A4 and CYP3A5 were assessed using Escherichia coli recombinant cell lines. CYP3A4-mediated metabolism predominated for many of the compounds studied. However, a number of drugs gave similar CL… CONTINUE READING