Comparative analysis of spontaneous and mycobacterial antigen-induced secretion of Th1, Th2 and pro-inflammatory cytokines by peripheral blood mononuclear cells of tuberculosis patients.


The cytokines produced by T helper (Th)1 cells (IFN-γ, IL-2 and TNF-β) correlate with protection, whereas the cytokines released by Th2 cells (IL-4, IL-5) and the anti-inflammatory cytokine IL-10 correlate with pathogenesis of tuberculosis (TB). However, the pro-inflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α and IL-12p70) are responsible for both… (More)
DOI: 10.1111/j.1365-3083.2012.02692.x


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