Comparative analysis of secreted proteins from normal and preeclamptic trophoblastic cells using proteomic approaches.

@article{Epiney2012ComparativeAO,
  title={Comparative analysis of secreted proteins from normal and preeclamptic trophoblastic cells using proteomic approaches.},
  author={Manuela Epiney and Pascale G Ribaux and Patrizia Arboit and Olivier Irion and Maurice Cohen},
  journal={Journal of proteomics},
  year={2012},
  volume={75 6},
  pages={1771-7}
}
Preeclampsia (PE) is a pathology of pregnancy which represents the main cause of maternal and perinatal morbidity and mortality. Defective placentation is the first event of this pathology. The purpose of this study was to identify the proteins secreted by cytotrophoblastic cells (CTB) using proteomic approach that are associated with PE. Comparison of secreted proteins by mass spectrometry allowed us to identify 21 proteins which were significantly differentially secreted by control and PE CTB… CONTINUE READING
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