Comparative analysis of rigidity across protein families.

  title={Comparative analysis of rigidity across protein families.},
  author={Stephen A. Wells and J. E. Jimenez-Roldan and Rudolf A. R{\"o}mer},
  journal={Physical biology},
  volume={6 4},
We present a comparative study in which 'pebble game' rigidity analysis is applied to multiple protein crystal structures, for each of six different protein families. We find that the main-chain rigidity of a protein structure at a given hydrogen bond energy cutoff is quite sensitive to small structural variations, and conclude that the hydrogen bond constraints in rigidity analysis should be chosen so as to form and test specific hypotheses about the rigidity of a particular protein. Our… CONTINUE READING