Comparative analysis of p53 gene mutations and protein accumulation in human non-small-cell lung cancer.

@article{Top1995ComparativeAO,
  title={Comparative analysis of p53 gene mutations and protein accumulation in human non-small-cell lung cancer.},
  author={Barbara Top and Wolter J. Mooi and Suzanne Klaver and Lucie Boerrigter and P Wisman and Heidi Elbers and Steven C. Visser and Sjoerd Rodenhuis},
  journal={International journal of cancer},
  year={1995},
  volume={64 2},
  pages={
          83-91
        }
}
A series of 54 resected primary non-small-cell lung carcinomas was analyzed for p53 gene mutations and for p53 protein accumulation and the findings were correlated with clinical parameters. Mutations in exons 5 through 8 of the p53 gene were identified by a denaturing gradient gel electrophoresis (DGGE) assay and cycle sequencing, whereas p53 protein accumulation was detected in paraffin-embedded tissue by immunostaining using 2 different murine monoclonal antibodies (MAbs) (BP53-12 and DO7… CONTINUE READING
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