Comparative analysis of osteoblast gene expression profiles and Runx2 genomic occupancy of mouse and human osteoblasts in vitro.

@article{Tarkkonen2017ComparativeAO,
  title={Comparative analysis of osteoblast gene expression profiles and Runx2 genomic occupancy of mouse and human osteoblasts in vitro.},
  author={Kati M. Tarkkonen and Reija Hieta and Ville Kyt{\"o}l{\"a} and Matti Nykter and Riku Kiviranta},
  journal={Gene},
  year={2017},
  volume={626},
  pages={119-131}
}
Fast progress of the next generation sequencing (NGS) technology has allowed global transcriptional profiling and genome-wide mapping of transcription factor binding sites in various cellular contexts. However, limited number of replicates and high amount of data processing may weaken the significance of the findings. Comparative analyses of independent data sets acquired in the different laboratories would greatly increase the validity of the data. Runx2 is the key transcription factor… CONTINUE READING
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