Comparative analysis of novel noninvasive renal biomarkers and metabonomic changes in a rat model of gentamicin nephrotoxicity.

@article{Sieber2009ComparativeAO,
  title={Comparative analysis of novel noninvasive renal biomarkers and metabonomic changes in a rat model of gentamicin nephrotoxicity.},
  author={Max Sieber and Dana Hoffmann and Melanie Adler and Vishal S. Vaidya and Matthew E Clement and Joseph V. Bonventre and Nadine Zidek and Eva Rached and Alexander Amberg and John. J. Callanan and Wolfgang Dekant and Angela Mally},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2009},
  volume={109 2},
  pages={336-49}
}
Although early detection of toxicant induced kidney injury during drug development and chemical safety testing is still limited by the lack of sensitive and reliable biomarkers of nephrotoxicity, omics technologies have brought enormous opportunities for improved detection of toxicity and biomarker discovery. Thus, transcription profiling has led to the identification of several candidate kidney biomarkers such as kidney injury molecule (Kim-1), clusterin, lipocalin-2, and tissue inhibitor of… CONTINUE READING

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