Comparative analysis of minimal residual disease detection by multiparameter flow cytometry and enhanced ASO RQ-PCR in multiple myeloma

@inproceedings{Silvennoinen2014ComparativeAO,
  title={Comparative analysis of minimal residual disease detection by multiparameter flow
cytometry and enhanced ASO RQ-PCR in multiple myeloma},
  author={Raija Silvennoinen and Tuija Lund{\'a}n and Veli Kairisto and T. T. Pelliniemi and Mervi Putkonen and P M Anttila and Virva Huotari and Pekka M{\"a}ntymaa and Sanna Siitonen and Lasse Uotila and T-L Penttil{\"a} and Vesa Juvonen and Tuomas A. Selander and Kari Remes},
  booktitle={Blood cancer journal},
  year={2014}
}
Multiparameter flow cytometry (MFC) and allele-specific oligonucleotide real-time quantitative PCR (ASO RQ-PCR) are the two most sensitive methods to detect minimal residual disease (MRD) in multiple myeloma (MM). We compared these methods in 129 paired post-therapy samples from 22 unselected, consecutive MM patients in complete/near complete remission. Appropriate immunophenotypic and ASO RQ-PCR-MRD targets could be detected and MRD analyses constructed for all patients. The high PCR coverage… CONTINUE READING
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