Comparative analysis of micronuclei and DNA damage induced by Ochratoxin A in two mammalian cell lines.

@article{Ali2011ComparativeAO,
  title={Comparative analysis of micronuclei and DNA damage induced by Ochratoxin A in two mammalian cell lines.},
  author={Rahat Ali and Roberta A. Mittelstaedt and Joseph G. Shaddock and Wei Ding and Javed Ahmad Bhalli and Qaiser Mahmood Khan and Robert H. Heflich},
  journal={Mutation research},
  year={2011},
  volume={723 1},
  pages={58-64}
}
The fungal toxin, Ochratoxin A (OTA), is a common contaminant in human food and animal feed. The present study evaluated micronucleus (MN) induction by OTA in comparison with its ability to induce cytotoxicity and DNA damage in two mammalian cell lines, CHO-K1-BH(4) Chinese hamster ovary cells and TK6 human lymphoblastoid cells. Micronuclei were evaluated by flow cytometry, cytotoxicity was estimated by relative population doubling (RPD), while direct DNA damage and oxidative DNA damage were… CONTINUE READING

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