Comparative analysis of methods for genome-wide nucleosome cartography

  title={Comparative analysis of methods for genome-wide nucleosome cartography},
  author={Luis Quintales and Enrique V{\'a}zquez and Francisco Antequera},
  journal={Briefings in bioinformatics},
  volume={16 4},
Nucleosomes contribute to compacting the genome into the nucleus and regulate the physical access of regulatory proteins to DNA either directly or through the epigenetic modifications of the histone tails. Precise mapping of nucleosome positioning across the genome is, therefore, essential to understanding the genome regulation. In recent years, several experimental protocols have been developed for this purpose that include the enzymatic digestion, chemical cleavage or immunoprecipitation of… CONTINUE READING
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