Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale.

@article{Wang2015ComparativeAO,
  title={Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale.},
  author={Yuhuan Wang and Vincent M. Hayes and Danuta J Jarocha and Xiuli Sim and Dawn C. Harper and Rudy Fuentes and Spencer K Sullivan and Paul Gadue and Stella T. Chou and Beverly J Torok-Storb and Michael S Marks and Deborah L. French and M. Poncz},
  journal={Blood},
  year={2015},
  volume={125 23},
  pages={3627-36}
}
Thrombopoiesis is the process by which megakaryocytes release platelets that circulate as uniform small, disc-shaped anucleate cytoplasmic fragments with critical roles in hemostasis and related biology. The exact mechanism of thrombopoiesis and the maturation pathways of platelets released into the circulation remain incompletely understood. We showed that ex vivo-generated murine megakaryocytes infused into mice release platelets within the pulmonary vasculature. Here we now show that infused… CONTINUE READING

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Competitive collagen IGPVI / collagen IV- α2β1-integrin signaling modulates proplatelet formation. Platelets. 8 International Platelet Symposium

  • R Kulawig, D Stegner, I Meyer, B Nieswandt, H. Schulze
  • 2014

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