Comparative analysis of genes encoding key steroid core oxidation enzymes in fast-growing Mycobacterium spp. strains.

  title={Comparative analysis of genes encoding key steroid core oxidation enzymes in fast-growing Mycobacterium spp. strains.},
  author={Eugeny Y. Bragin and Victoriya Y. Shtratnikova and Dmitry V. Dovbnya and Mikhail I Schelkunov and Yu A Pekov and Sophie G. Malakho and Olga V. Egorova and Tatyana V Ivashina and Sergei L. Sokolov and Vasily V. Ashapkin and Marina V. Donova},
  journal={The Journal of steroid biochemistry and molecular biology},
A comparative genome analysis of Mycobacterium spp. VKM Ac-1815D, 1816D and 1817D strains used for efficient production of key steroid intermediates (androst-4-ene-3,17-dione, AD, androsta-1,4-diene-3,17-dione, ADD, 9α-hydroxy androst-4-ene-3,17-dione, 9-OH-AD) from phytosterol has been carried out by deep sequencing. The assembled contig sequences were analyzed for the presence putative genes of steroid catabolism pathways. Since 3-ketosteroid-9α-hydroxylases (KSH) and 3-ketosteroid-Δ(1… CONTINUE READING


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