Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains.

@article{Kuo2001ComparativeAO,
  title={Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains.},
  author={Y M Kuo and Tyler A. Kokjohn and Thomas Gerald Beach and Lucia I. Sue and Daniel Brune and Jorge Alberto Cruz L{\'o}pez and Walter M. Kalback and Doroth{\'e}e Abramowski and Christine Sturchler-Pierrat and Matthias Staufenbiel and Alex E. Roher},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 16},
  pages={
          12991-8
        }
}
We have undertaken an integrated chemical and morphological comparison of the amyloid-beta (Abeta) molecules and the amyloid plaques present in the brains of APP23 transgenic (tg) mice and human Alzheimer's disease (AD) patients. Despite an apparent overall structural resemblance to AD pathology, our detailed chemical analyses revealed that although the amyloid plaques characteristic of AD contain cores that are highly resistant to chemical and physical disruption, the tg mice produced amyloid… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 81 CITATIONS, ESTIMATED 53% COVERAGE

Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2002
VIEW 4 EXCERPTS
CITES BACKGROUND

APP Transgenic Mice: Their Use and Limitations

  • NeuroMolecular Medicine
  • 2010
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases

  • Journal of Neural Transmission
  • 2009
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2001
2018

CITATION STATISTICS

  • 9 Highly Influenced Citations