Comparative analysis of amino acid metabolism and transport in CHO variants with different levels of productivity.


Chinese hamster ovary (CHO) cells are widely used for the production of biopharmaceuticals; however, our understanding of several physiological elements that contribute to productivity is limited. One of these is amino acid transport and how its limitation and/or regulation might affect productivity. To further our understanding, we have examined the… (More)
DOI: 10.1016/j.jbiotec.2013.09.007