Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes.

@article{Mattioli2004ComparativeAO,
  title={Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes.},
  author={Ivan Mattioli and Oliver Dittrich-Breiholz and Mark Livingstone and Michael Kracht and Michael Schmitz},
  journal={Blood},
  year={2004},
  volume={104 10},
  pages={3302-4}
}
The CD43 lymphocyte surface receptor is involved in the regulation of lymphocyte adhesion and activation. Many CD43 functions remain controversial or unclear, and it is not known to which extent CD43 signaling pathways are shared with or distinct from those used by the T-cell receptor (TCR). Here, we systematically compared signaling events and target gene expression induced by CD43 or T-cell costimulation in primary human peripheral T cells. These studies identify nuclear factor-kappaB (NF… CONTINUE READING

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